Pentafluorophenol-Catalyzed Metal-Free Fischer Indole Synthesis: A Novel Approach to Carbazole Derivatives and Desbromoarborescidine A.

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Tác giả: Diksha Bansal, Saikat Chaudhuri, Mrinal Kanti Das, Chibisree Elanchezhian, Gokulprasanth Nataraj, Pooja Sivaganesan

Ngôn ngữ: eng

Ký hiệu phân loại: 546.382 *Sodium

Thông tin xuất bản: Germany : Chemistry, an Asian journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 738454

Carbazoles represent significant heterocyclic compounds with a wide range of applications in organic synthesis. Conventional techniques, such as the Fischer indole synthesis, have been extensively utilized for the construction of these structures. In this study, we report the first use of pentafluorophenol (PFP) as a catalyst in a metal-free approach for the synthesis of carbazoles. The strong electron-withdrawing properties and low pKa of PFP facilitate the effective activation of electrophiles, leading to improved yields and selectivity. A comprehensive exploration of substrate diversity has been conducted, resulting in the synthesis and thorough characterization of various carbazole derivatives using
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