Dynamic property of central airway walls assessed by computed tomography: correlation with asthma pathophysiology.

• Tác giả: Makiko Jinnai, Hisako Matsumoto, Michiaki Mishima, Yasutaka Nakano, Akio Niimi, Tsuyoshi Oguma, Masaya Takemura, Tetsuya Ueda, Masafumi Yamaguchi
• Ngôn ngữ: eng
• Thông tin xuất bản: England : The Journal of asthma : official journal of the Association for the Care of Asthma , 2025
• Bộ sưu tập: NCBI
• ID: 738464

Tóm tắt

OBJECTIVE: A subset of asthmatics suffers from frequent exacerbations. Various features of airway remodeling and the resultant elastic property of airway walls may play pathophysiological roles in these exacerbations. The aim of the study was to examine the collapsibility of airways and sputum biomarkers associated with airway remodeling with different frequencies of exacerbations. METHODS: We studied 29 moderate-to-severe asthmatics classified by the number of exacerbations in the previous year as, ≤1: stable, RESULTS: Airway collapsibility was greater in difficult asthmatics than in stable asthmatics and HC. Sputum TGF-β CONCLUSIONS: Collapsibility of thickened airway walls may determine their susceptibility to exacerbations. This may depend on the balance between fibrosis and angiogenesis/edema in the airways.