Plasma extracellular vesicles promote follicular T helper cell expansion in primary Sjögren's syndrome.

• Tác giả: Hua Chen, Zhilei Chen, Chengmei He, Suying Liu, Chaowen Luo, Taibiao Lyu, Lin Qiao, Jinlei Sun, Fengchun Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Clinical immunology (Orlando, Fla.) , 2025
• Bộ sưu tập: NCBI
• ID: 738508

Tóm tắt

Primary Sjögren's syndrome (pSS) is a prevalent autoimmune disease characterized by exocrine gland dysfunction, with hallmarks of B cell and T cell overactivation, whose underlying mechanism remains largely unknown. Herein, we show that pSS plasma contained more extracellular vesicles (EVs) than HC plasma, which promoted CD4