HDAC6 deficiency aggravates ductular reactions through aggresome-mediated hepatocyte apoptosis.

• Tác giả: Guoquan Fu, Lifang Jin, Shanshan Tan, Xueying Xie, Yixia Xie, Junyan Yan
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Biochemical and biophysical research communications , 2025
• Bộ sưu tập: NCBI
• ID: 738603

Tóm tắt

Ductular reactions (DRs) contribute significantly to the occurrence and development of liver disease. While histone deacetylase 6 (HDAC6) is known to regulate injury repair in multiple tissues, its exact role in DRs remains unclear. This study examined the role and underlying mechanism of HDAC6 in DRs using an HDAC6 knockout (HDAC6