Synthesis and in vitro and in vivo evaluation of novel bivalent quinolines as antitumor agents via targeting autophagy in cervical cancer.

• Tác giả: Shishen Ai, Rihui Cao, Yuzhen Chen, Yuexiu Liang, Wenxian Lin, Liqin Qiu, Junli Wang, Weijie Yang, Xiaoyu Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 738616

Tóm tắt

A series of novel bivalent quinolines with a spacer of four to six methylene units between the phenoxy group in the position-7 and various substituents in the position-4 of quinoline skeleton, respectively, were synthesized and evaluated as anticancer agents. The data showed that the majority of the compounds had significant antiproliferative activity with IC