Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators.

• Tác giả: Qing Cao, Zi-Tong Cao, Li-Xin Gao, Jia Li, Xu-Yang Mu, Wen-Long Wang, Da-Jun Xiang, Chun Zhang, Zhen-Xuan Zhang, Yu-Bo Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 738624

Tóm tắt

The development of small fluorescent organic molecules used in bioimaging experiment has boomed the progress of molecular and cellular biology, providing new and efficient tools to elucidate a myriad of cellular and multicellular processes. In this work, a class of fluorescent activators against SHP1 was designed and synthesized for the first time. The representative compound 3n showed activating effect against SHP1 with EC