Vascular E-selectin Expression Recognized by the U12-12 Monoclonal Antibody as a Predictive Marker for Steroid Resistance in Immune Checkpoint Inhibitor-related Colitis.

• Tác giả: Katsushi Hiramatsu, Tamotsu Ishizuka, Mai Iwaya, Motohiro Kobayashi, Tadanobu Nagaya, Yasunari Nakamoto, Koki Nakashima, Takeshi Uehara
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society , 2025
• Bộ sưu tập: NCBI
• ID: 738703

Tóm tắt

 In immune checkpoint inhibitor (ICI)-related colitis, tumor necrosis factor (TNF)-α blockade is recommended if symptoms are not alleviated with corticosteroids. Although TNF has been shown to be associated with steroid resistance, the early prediction of steroid resistance is challenging in clinical practice. Therefore, in the present study, we evaluated the potential of vascular E-selectin expression, which is induced by TNF, to serve as a predictor of steroid resistance in ICI-related colitis. We performed immunohistochemical analysis of 29 cases of ICI-related colitis using the U12-12 monoclonal antibody, which specifically recognizes E-selectin, and examined the association between U12-12 staining and clinical features. The result showed that the proportion of steroid-resistant cases was significantly higher in the U12-12-positive group (8 of 9 cases
  88.9%) than in the U12-12-negative group (1 of 20 cases
  5.0%) (