Discovery and optimization of phenazopyridine hydrochloride as novel SARS-CoV-2 RdRp inhibitors.

• Tác giả: Shan Cen, Saisai Guo, Jiabin Li, Quanjie Li, Xiaoyu Li, YaSheng Li, Tianfu Liu, Ling Ma, Yu Shi, Wenjie Tan, Yucheng Wang, Yujia Wang, Dongrong Yi, Guoning Zhang, Jianyuan Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 769.565 *Covers
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 738737
• Chủ đề: 1. Discovery; 2. And; 3. Optimization

Tóm tắt

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen of coronavirus disease (COVID-19) causing a pandemic with growing global transmission. The viral RNA-dependent RNA polymerase (RdRp) is conserved especially for variants of concern (VOCs), making it as an effective antivirals target. Due to the proofreading activity of coronavirus nsp14/nsp10, limited the efficacy of nucleoside analogs in vivo. Herein, we identified that Phenazopyridine hydrochloride (PAP) inhibits SARS-CoV-2 with EC