Most research on the vaginal microbiome has focused on bacterial communities (the bacteriome), but viruses, including eukaryotic viruses and bacteriophages, are also important players in vaginal health and disease states. In this review, we will briefly discuss the bacterial microbiome, delve into what is known about the vaginal virome and its impact on women's health, and finish with novel vaginal microbial or microbial-derived therapeutics on the horizon. More studies on the vaginal virome and its impact on women's health are needed to better prevent and treat gynecological, reproductive, and neonatal diseases.