Discovery of Novel Pyrrolo[2,3-

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Tác giả: Rongrong Dong, Wen Gao, Jinting He, Lihong Hu, Lin Li, Qi Lv, Yingshan Lv, Junwei Wang, Xiaolong Xie, Qiang Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 769.565 *Covers

Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 738843

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Repolarizing M2-like tumor associated macrophages (TAMs) into M1 phenotype by blocking CSF-1/CSF-1R signaling pathway represents a promising strategy to remodel the tumor immune microenvironment. Therefore, the discovery of novel potent CSF-1R inhibitors is of great significance for colorectal cancer immunotherapy. In this work, a series of novel CSF-1R inhibitors were designed and synthesized through rational molecular hybridization strategy and step by step structural optimization based on PLX3397 and BLZ945. Among these derivatives, compound

1. Discovery
2. Of
3. Novel

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