Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid.

• Tác giả: Ching-Ping Chen, Chiung-Tong Chen, Ya-Hui Chi, Tai-Yu Chiu, Wan-Chi Hsiao, Chih-Chien Hsieh, Shu-Ching Hsu, Chen-Lung Huang, Wei-Cheng Huang, Yi-Ping Kuo, Po-Hsun Lee, Guang-Hao Niu, Ping-Jyun Sung, Lun Kelvin Tsou, Chun-Wei Tung, Chien-Ming Wang, Jing-Ya Wang, Zhi-Hong Wen, Yu-Shao Yang, Teng-Kuang Yeh, May-Su You, Guann-Yi Yu, Mingzi M Zhang, Li-Guo Zheng
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 738844

Tóm tắt

Pharmacological inhibition of the cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad of inflammatory diseases. Here, we report