Design, synthesis and molecular dynamics simulations of thiazole-based hydrazones targeting MDA-MB-231 breast cancer cells.

• Tác giả: Shankar G Alegaon, Shankar Gharge, Sachin Gudasi, Manjula I Kambi, Rohini S Kavalapure, Vijay M Kumbar, Deepa R Mane, Pravin C Mhaske, Sunidhi Patil, Shriram D Ranade, Shahana Shahpuri, Niteen R Sutar
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Bioorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 739021

Tóm tắt

This study presents the design, synthesis of thiazole-based Hydrazones as potential inhibitors targeting in MDA-MB-231 triple-negative breast cancer cells. A series of quinazoline-thiazole and isatin-thiazole derivatives were synthesized and evaluated for their anti-proliferative activity. Compounds 12d and 12f (quinazoline-thiazole) demonstrated significant inhibitory effects, with IC