Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation.

• Tác giả: Sherien A Abdelhady, Mahmoud A Agami, Ahmed S F Belal, Ali H Eid, Reem H Elhamammy, Mai S El-Shoukrofy, Ahmed F El-Yazbi, Perihan A Elzahhar, Azza Ismail, Monica S Makkar, Daniel Merk, Rasha Nassra, Hisham A Nematalla, Minh Sai, Ahmed Wahid
• Ngôn ngữ: eng
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 739053

Tóm tắt

A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC