BACKGROUND: Primary healthcare practitioners play a key role in the comprehensive care of epilepsy. People with epilepsy require suitable guidance for self-management to enhance their health and well-being. The aim was to evaluate knowledge, attitudes, and practices about epilepsy management among the primary healthcare professionals. METHODS: Cross-sectional quantitative research was employed. Healthcare professionals working in primary healthcare clinics completed an online, self-administered questionnaire between April and June 2024. RESULTS: Three hundred valid questionnaires were analyzed. Healthcare professionals demonstrated moderate knowledge, favorable attitudes, and proactive practices in epilepsy management. Pearson's correlation revealed a significant negative relationship between practices and knowledge (r = -0.170, p <
0.01) and a positive association with attitudes (r = 0.279, p <
0.01). Multivariate analysis showed that knowledge were negatively correlated with gender and specialty but positively with educational degree (OR = 0.640, 95 % CI: 1.260-0.020, p = 0.043
OR = 1.970, 95 % CI: 2.841-0.099, p <
0.002). Attitudes were positively associated with age (OR = 2.552, 95 % CI: 0.974-4.130, p = 0.002) and years of experience (OR = 2.387, 95 % CI: 0.546-4.227, p = 0.011). CONCLUSIONS: Findings indicate gaps in epilepsy knowledge, attitudes, and practices. The study underscores the need for comprehensive training initiatives in Palestine to enhance epilepsy management in primary healthcare settings.