Novel ꞵ-carboline/cyanoisoflavone photosensitizers for ferroptosis-induced efficient chemo-photodynamic synergistic cancer therapy.

• Tác giả: Dongliang Ji, Chang-Chun Ling, Yong Ling, Xiao Liu, Tiantian Sun, Lei Wang, Sijia Wang, Xudong Xie, Ruiqi Yang
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Journal of photochemistry and photobiology. B, Biology , 2025
• Bộ sưu tập: NCBI
• ID: 739169

Tóm tắt

Photodynamic therapy (PDT) is an emerging therapeutic modality to selectively eradicate pathological cells, such as cancer cells. Hence, we designed and synthesized a series of novel ꞵ-carboline/cyanoisoflavone photosensitizers A1-A3. All compounds possessed potent type-I/-II photodynamic properties. Especially, the optimized compound A2 produced large amounts of •O