In this article, we present the case of a 42-year-old woman with an asymptomatic papulonodular lesion on her right forearm appearing approximately two years before. An excisional biopsy subsequently yielded a histological diagnosis of nodular hidradenoma (NH). This case highlights the clarity of the clinical, dermatoscopic and histopathological images. We also discuss the need to consider other differential diagnoses, some of which are malignant, such as hydroadenocarcinoma, basal cell carcinoma, and amelanotic melanoma. By sharing this case, we aim to contribute to the dermatological and pathological community's knowledge, promote discussion of diagnostic strategies, and emphasize the importance of interdisciplinary collaboration.