Water reservoirs are facing increasing prevalence of microcontaminants originating from agricultural runoff, industrial effluents, and domestic wastewater. The persistence of microcontaminants leads to disruptions in aquatic ecosystems and poses potential long-term health risks to humans, even at minimal concentrations. However, traditional wastewater treatment methods are inefficient to eliminate the microcontaminants because of their intricate chemical structures and low concentration. In this regard, nano-adsorption employing nanomaterials as adsorbents presents a viable alternative, offering enhanced efficiency and specificity towards the removal of microcontaminants. Amongst all, two-dimensional (2D) nanomaterials, including graphene oxide (GO), layered double hydroxides (LDHs), MXenes, and boron nitrides (BNs), exhibit distinctive characteristics such as a high surface area, remarkable chemical stability, and tendency of diverse surface functionalization, rendering them particularly effective in adsorbing pollutants from water. Therefore, the present review provides an exhaustive literature and comparative analysis of the aforementioned 2D nanomaterials-based adsorbents concerning their efficacy in adsorbing microcontaminants of pharmaceuticals and personal care products origin such as antibiotics, steroids, bisphenols, phthalates, parabens, and benzophenones. The different aspects of 2D adsorbents including adsorption capacity, mechanisms involved, kinetic and isotherm models followed for removal of a variety of microcontaminants have been congregated. Also, the information on recyclability, reusability, and stability of the adsorbents has been summarized to highlight their viability. Further, the limitations and future aspects related to the use of 2D nanomaterials-based adsorbents towards pollutant removal have been discussed. Overall, 2D nanomaterials holds great promise as efficient adsorbents for environmental remediation and can also be explored for industrial adsorption applications.