Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines.

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Tác giả: Hiroshi Ageta, Natsumi Ageta-Ishihara, Fumiko Arima-Yoshida, Haruhiko Bito, Kazuto Fujishima, Yugo Fukazawa, Hiroyuki Hioki, Kaoru Inokuchi, Yuichiro Ishii, Mineko Kengaku, Makoto Kinoshita, Kohtarou Konno, Toshiya Manabe, Tsuyoshi Miyakawa, Hiroyuki Okuno, Yoshikatsu Sato, Keizo Takao, Kunihiro Tsuchida, Ayako M Watabe, Masahiko Watanabe

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Cell reports , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 739314

Transient memories are converted to persistent memories at the synapse and circuit/systems levels. The synapse-level consolidation parallels electrophysiological transition from early- to late-phase long-term potentiation of synaptic transmission (E-/L-LTP). While glutamate signaling upregulations coupled with dendritic spine enlargement are common underpinnings of E-LTP and L-LTP, synaptic mechanisms conferring persistence on L-LTP remain unclear. Here, we show that L-LTP induced at the perforant path-hippocampal dentate gyrus (DG) synapses accompanies cytoskeletal remodeling that involves actin and the septin subunit SEPT3. L-LTP in DG neurons causes fast spine enlargement, followed by SEPT3-dependent smooth endoplasmic reticulum (sER) extension into enlarged spines. Spines containing sER show greater Ca
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