Outer radial glia promotes white matter regeneration after neonatal brain injury.

• Tác giả: Artur Agaronyan, Vittorio Gallo, Kazue Hashimoto-Torii, Soichiro Henmi, Yuka Imamura, Nobuyuki Ishibashi, Hideo Jinnou, Kazuya Kuboyama, Van K Lam, Jaya Prasad, Lauren M Rosko, Kazunobu Sawamoto, Tsang-Wei Tu, Satoshi Yamashita
• Ngôn ngữ: eng
• Ký hiệu phân loại: 352.744 *Promoting libraries and historical research
• Thông tin xuất bản: United States : Cell reports. Medicine , 2025
• Bộ sưu tập: NCBI
• ID: 739326

Tóm tắt

The developing gyrencephalic brain contains a large population of neural stem cells in the ventricular zone and outer subventricular zone (OSVZ), the latter populated by outer radial glia (oRG). The role of oRG during postnatal development is not well understood. We show that oRG cells increase proliferative capacity and contribute to oligodendrocyte precursor cell (OPC) production following brain injury in human infants and neonatal piglets, whose brains resemble the human brain in structure and development. RNA sequencing revealed oRG-specific transcriptional responses to injury in piglets and showed that the activating transcription factor 5 (ATF5) pathway positively regulates oRG proliferation. Intranasal activation of ATF5 using salubrinal enhanced OSVZ-derived oligodendrogenesis in the injured periventricular white matter and improved functional recovery. These results reveal a key role for postnatal oRG in brain injury recovery and identify ATF5 as a potential therapeutic target for treating white matter injury in infants.