Palmitic acid-induced insulin resistance triggers granulosa cell senescence by disruption of the UPR

• Tác giả: Hui Gao, Xiaoqiang Luo, Pengge Pan, Yaqi Sun, Yuan Tian, Xintong Yang, Yanzhou Yang
• Ngôn ngữ: eng
• Thông tin xuất bản: Ireland : Chemico-biological interactions , 2025
• Bộ sưu tập: NCBI
• ID: 739446

Tóm tắt

Insulin resistance (IR) is the main pathological feature of polycystic ovary syndrome (PCOS), but the adverse impacts of IR on ovary and granulosa cells (GCs) are unknown. Therefore, the role of palmitic acid (PA) induced IR in GCs, and a mitochondrial proteostasis and mitochondrial homeostasis control system, the mitochondrial unfolded protein response (UPR