Metformin alleviates auditory cell senescence by mitophagy induction.

• Tác giả: Sung Il Cho, Hee Sun Jang, Eu-Ri Jo
• Ngôn ngữ: eng
• Thông tin xuất bản: Ireland : Neuroscience research , 2025
• Bộ sưu tập: NCBI
• ID: 739553

Tóm tắt

Age-related hearing loss is the most common type of hearing loss in older adults. However, its underlying cellular mechanism is still unclear. Impaired mitochondrial function is a hallmark of various age-related pathologies. To maintain mitochondrial function in senescent cells, mitophagy is a crucial process for dysfunctional mitochondria turnover. Metformin has been reported to induce mitophagy. This study aimed to investigate the effect of metformin on preventing senescence in auditory cells. Low-dose H