The depletion of fossil resources, the energy crisis, and environmental pollution have become the main drivers for transitioning from a linear petroleum refinery to a sustainable biorefinery. In the current scenario, the global scientific community is focused on developing a sustainable and green environment. To this end, exclusive efforts have been made in waste valorization and management. Lignocellulosic biomass remains the most abundant and underutilized renewable biomaterial on Earth, offering a sustainable production of various value-added products like biofuels and other platform chemicals. This study aims to develop a sustainable biorefinery approach utilizing Madhuca indica biomass for biofuel and biopolyol production, addressing fossil fuel depletion and environmental concerns. The integrated process enhances resource valorization while ensuring economic feasibility and carbon neutrality. Under the optimum conditions of 12 % w/v deoiled cake, 5 % w/v substrate-to-inoculum ratio (S: I), and 0.3 % w/w cow dung-to-anerobic sludge ratio (CD: AS), the greatest biohydrogen production was achieved. The total yield percentage of biodiesel was found to be 82.86 %. The produced biodiesel underwent characterization using FTIR, H-NMR, and GC-MS. Madhuca indica biomass was liquefied into polyol successfully, with a biomass conversion rate of 91 % under optimal reaction conditions. The produced Bio Polyols were further characterized by FTIR and GC-MS. Using the Aspen Plus Economic Analyzer, the biorefinery process payback period for the biodiesel, biohydrogen, and biopolyol produced from M. indica was found to be 4.39 years. Techno-economic analyses show that biorefinery technology is highly profitable and beneficial. The present work, therefore, demonstrates ways to exploit the Madhuca indica seed biorefinery to generate carbon-neutral energy sources and products.