A Cryptococcus neoformans polysaccharide conjugate vaccine made with filtered polysaccharide elicits protective immunity in mice.

• Tác giả: Arturo Casadevall, Livia C Liporagi Lopes, Scott A McConnell, Paola Ramos Irizarry, Samuel Rodrigues Dos Santos Júnior, Piotr R Stempinski, Maggie P Wear
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Fungal biology , 2025
• Bộ sưu tập: NCBI
• ID: 739703

Tóm tắt

Diseases caused by the encapsulated fungus Cryptococcus neoformans are major causes of mortality and morbidity in immunocompromised patients. Two important cryptococcal virulence factors are the polysaccharide capsule (CPS) and the secreted exopolysaccharides (EPS), both of which contain predominantly glucuronoxylomannan (GXM) polymers. Here, we evaluated the efficacy of an experimental glycoconjugate vaccine generated by linking minimally processed cryptococcal EPS with the protein carrier CRM