Tuberculosis (TB) in multiple organs, especially central nervous system TB (brain abscess due to TB), often occurs in patients with severe immunodeficiency, related to HIV infection, organ transplantation, etc., rarely seen in clinical practice. Due to the complexity of the variation, prediction and treatment are difficult. Only predictive testing and necessary treatment solutions must be based on the specific state of the disease. In addition to anti-TB antibiotic therapy, addressing symptoms and implementing preventive measures are crucial for successful treatment outcomes in patients.