Non-thermal treatments are current trends in food safety, the application of these technologies may lessen the influence of heat on food quality. The non-thermal food preservation techniques enable the food industry to meet regulations for product safety and shelf life. Common non-thermal techniques include cold plasma, ionizing radiation, ultraviolet light, pulsed electric fields, and high-pressure processing. This chapter provides a quick summary of the most current uses of these technologies for food preservation. In addition, a succinct description of the process used to inactivate foodborne microorganisms in food has been provided.