Foodborne diseases affect millions of people globally, resulting in a huge number of hospitalizations and deaths. In this context, laboratory-based research is crucial to identify the major pathogens as well as the relevance of each one for distinct food production chains. Pork meat is very popular, being the most consumed meat in many countries and its inspection at the slaughterhouse is the main component of surveillance to protect consumers. Healthy pigs may carry pathogenic and antibiotic resistant bacteria that can be subsequently transferred to humans through the consumption of contaminated meat. Further, the food processing environment can harbor pathogenic persistent bacteria, representing a risk of cross-contamination to pork meat, demanding strict slaughtering procedures. Among these foodborne bacteria, Salmonella, Yersinia enterocolitica, Escherichia coli, Campylobacter spp., Listeria monocytogenes and Staphylococcus aureus are the most relevant in the pork production chain. Molecular subtyping has been fundamental for pathogen detection and also to track transmission, and nowadays it is a key component of the efforts to prevent and control foodborne diseases. In this chapter, characteristics of these major foodborne bacteria associated to pork meat will be addressed, including their occurrence and importance along the pork production chain, worldwide distribution, typing, as well as control and prevention measures from farm to fork.