Three years is the minimal effective duration of sustained clinical remission which prevents impaired kidney function and damage accrual in lupus nephritis.

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Tác giả: Elisa Bellis, Marta Calatroni, Claudio Cruciani, Andrea Doria, Giulia Frontini, Claudia Furlan, Mariele Gatto, Luca Iaccarino, Gabriella Moroni, Francesco Reggiani, Renato Alberto Sinico

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Annals of the rheumatic diseases , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 739905

 OBJECTIVES: To assess the minimum effective duration of remission preventing damage accrual (Systemic Lupus International Collaborating Clinics damage index [SDI]) and impaired kidney function (IKF: estimated glomerular filtration rate of <
 60 mL/min/1.73 m METHODS: Patients with biopsy-proven LN followed up at least twice yearly were enrolled
  clinical variables were collected regularly. Sustained clinical remission (sCR) was defined as estimated glomerular filtration rate of >
 60 mL/min/1.73 m RESULTS: In total, 293 patients with LN were included (median follow-up: 15.7 [10.4-22.9] years) of whom 84.3% achieved sCR lasting 8.7 (5.4-13.1) years. At last observation, the increase in SDI was higher in patients who never achieved sCR (median: 2 [1-2.5] vs 1 [0-1.5]
  P <
  .002). A minimum duration of 3 years of sCR prevented SDI increase (% change = -41.1%
  P = .003). The analysis on IKF involved only patients with the longest follow-up
  224 patients had ≥10 years of observation. Among them, 50 (22.3%) developed IKF. A minimum duration of 3 years of sCR prevented IKF (hazard ratio = 0.10
  P <
  .002). IKF-free survival rate at 10, 20, and 25 years was 87%, 68%, and 40% for patients who never achieved sCR and 99%, 96%, and 91% for patients with at least 3 years of sCR, respectively (P <
  .002). CONCLUSIONS: Three years is the minimum duration of sCR protecting against development of IKF and damage accrual in patients with LN.
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