Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022-2023.

• Tác giả: Adugna Abera, Abraham Ali, Cheryl Baxter, Mahlet Belachew, Dereje Beyene, Molalegne Bitew, Lucious Chabuka, Tulio de Oliveira, Tobias F Rinke de Wit, Jennifer Giandhari, Carmen Huber, Kamran Khan, Moritz U G Kraemer, Richard Lessells, Monika Moir, Gaspary Mwanyika, Sureshnee Pillay, Jenicca Poogavanan, Feyisa Regasa, Geremew Tasew, Houriiyah Tegally, Getachew Tollera, Derek Tshiabuila, Eduan Wilkinson, Dawit Wolday
• Ngôn ngữ: eng
• Ký hiệu phân loại: 346.029 Agency and quasi contract
• Thông tin xuất bản: United States : Emerging infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 739967

Tóm tắt

 In Ethiopia, dengue virus (DENV) infections have been reported in several regions
  however, little is known about the genetic diversity of circulating viruses. We conducted clinical surveillance of DENV during the 2023 nationwide outbreak in Ethiopia. We enrolled patients at 3 sentinel hospital sites. Using reverse transcription PCR, we screened serum samples for 3 arboviruses and then serotyped and whole-genome sequenced DENV-positive samples. We detected DENV-1 and DENV-3 serotypes. Phylogenetic analysis identified 1 transmission cluster for DENV-1 (genotype III major lineage A) and 2 clusters for DENV-3 (genotype III major lineage B). The first DENV-3 cluster was closely related to an isolate from a 2023 dengue outbreak in Italy
  the second cluster was related to isolates from India. Co-circulation of DENV-1 and DENV-3 in Ethiopia highlights the potential for severe dengue. Intensified surveillance and coordinated public health responses are needed to address the threat of severe dengue outbreaks.