Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy.

• Tác giả: Anna Laura Calvanese, Héctor Castañón, Virginia Cecconi, Michael Herbst, Hakan Köksal, Marc Nater, Joshua Panier, Steve Pascolo, Paulo Pereira, Paulino Tallón de Lara, Maries van den Broek
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 740004

Tóm tắt

Metastases arise from disseminated cancer cells (DCCs) that detach from the primary tumor and seed distant organs. There, quiescent DCCs can survive for an extended time, a state referred to as metastatic dormancy. The mechanisms governing the induction, maintenance, and awakening from metastatic dormancy are unclear. We show that the differentiation of dormancy-inducing CD8