OBJECTIVE: Aim: To analyze the impact of concurrent periodontal and maxillofacial diseases on the mental state and quality of life of patients aged 18-60 years for future comprehensive rehabilitation. PATIENTS AND METHODS: Materials and Methods: A total of 61 patients (aged 28-60 years) with periodontal diseases and concomitant maxillofacial disorders were studied. All patients had a dental examination, accompanied by assessments of anxiety, depression, and self-esteem with the Hospital Anxiety and Depression Scale (HADS), the Dembo-Rubinstein self-assessment method, and the Chaban Quality of Life Scale (CQLS). RESULTS: Results: The analysis of the HADS A score revealed that 31.1% of patients had a clinical level of anxiety, whereas 41% of patients had a subclinical level of anxiety. Based on the HADS D score, 21.3% of patients had a clinical level of depression, whereas 50.8% had a subclinical level of depression. The aspects of appearance, health, and confidence are highly correlated with patients' mental well-being. The quality of life assessment indicates that the majority of patients with concurrent periodontal and maxillofacial diseases experience a low or moderate quality of life. CONCLUSION: Conclusions: Patients with periodontal and maxillofacial diseases require not only dental care but also comprehensive rehabilitation, since appearance and physical health have a major impact on their quality of life.