OBJECTIVE: Aim: To assess the effects of honey and its derivatives on oral health. PATIENTS AND METHODS: Materials and methods: PubMed, Google Scholar, Scopus, Embase, Cochrane databases were searched using relevant keywords and Boolean operators. CONCLUSION: Conclusions: Honey is a promising natural alternative for the treatment of various dental diseases due to its antimicrobial, anti-inflammatory and wound-healing properties. Scientific studies show that honey has numerous health properties, including antibacterial, antiviral, anti-inflammatory, wound-healing and anticancer effects. In the context of dentistry, honey shows potential in the treatment of various oral conditions, such as dental caries, gingivitis, halitosis, radiotherapy-induced mucositis, xerostomia or post-extraction stomatitis. Honey's safety and multifunctional benefits make it a valuable potential addition to dental treatments.