Hydrogen sulfide improves depression-like behaviors in CUMS-induced mice by regulating autophagy.

• Tác giả: Wenlong Du, Xin Hao, Zhiqiang He, Qingqing Kong, Zhaoke Ling, Jiao Liu, Jie Liu, Ruiyao Liu, Yi Liu, Yushi Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.5266 Astrology
• Thông tin xuất bản: England : Psychoneuroendocrinology , 2025
• Bộ sưu tập: NCBI
• ID: 740049
• Chủ đề: 1. Hydrogen; 2. Sulfide; 3. Improves

Tóm tắt

The pathogenesis of depression is associated with synaptic impairment and dysfunction in autophagy processes. Mendelian randomization (MR) analysis revealed that six GWAS IDs revealed a significant association between Beclin-1 levels and depression risk. Besides, all SNPs had a positive effect on depression risk. Analyzing neurons from depressed individuals using single-cell RNA sequencing (scRNA-seq) uncovered decreased expression of AKT, mTOR, and genes linked to synaptic plasticity. The activation of the PI3K/AKT/mTOR signaling has been demonstrated to control autophagy and have a protective effect on the nervous system. Hydrogen sulfide (H