Exposure-response relationship of mycophenolic acid in pediatric lupus nephritis patients receiving multi-target therapy: An observational cohort study.

• Tác giả: Lizhi Chen, Pan Chen, Zhijun Huang, Xiaoyun Jiang, Baojing Liu, Xiaohong Liu, Kejing Tang, Lu Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Seminars in arthritis and rheumatism , 2025
• Bộ sưu tập: NCBI
• ID: 740227

Tóm tắt

OBJECTIVE: To establish the effectiveness threshold of mycophenolic acid-area under the concentration-time curve between 0 h and 12 h (MPA-AUC METHODS: This observational cohort study enrolled 48 pediatric LN patients treated with mycophenolate mofetil (MMF), tacrolimus, and prednisone. MPA-AUC RESULTS: To achieve renal remission, the MPA-AUC CONCLUSION: There is a significant correlation between MPA-AUC