Design, synthesis and activity evaluation of 4-(quinoline-2-yl)aniline derivatives as SARS-CoV‑2 main protease inhibitors.

• Tác giả: Honglei Bao, Zhenya Du, Shilin Gong, Yaguo Gong, Chunhua Ma, Qinhai Ma, Hui Meng, Gao Tu, Yuwei Wang, Jianlin Wu, Xiaojun Yao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 740297

Tóm tắt

Since 2020, numerous compounds have been investigated for their potential use in treating SARS-CoV-2 infections. By identifying the molecular targets during the virus replication process, rationally designed anti-SARS-CoV-2 agents are developed. Among these targets, the main protease (M