An efficient and antifouling cutting-edge membrane was fabricated via growing hierarchical ZnAl-layered double hydroxides (LDHs) nanosheets on the wood template for enhanced separation of immiscible oil/water mixtures and emulsions. The retained vertical channels within the wood substrate facilitated impressive liquid flux, while the LDHs layer coated on the wood surface establishes a robust hydration layer that effectively repels oil droplets. The synergistic effect of these two elements enables efficient separation of immiscible oil/water mixtures and emulsions. The ZnAl-LDHs/wood membrane demonstrates a remarkable reduction in oil adhesion, achieving exceptional antifouling performance. This innovative membrane was adept at efficiently separating oil/water mixtures, exhibiting an impressive flux of 1.87 × 10