Glomerular CD68

• Tác giả: Wei Cao, Ansheng Cong, Shuang Cui, Zuoyu Hu, Zhijie Huang, Jiao Luo, Cailing Su, Guobao Wang, Heng Wu, Dongyan Xu, Manqiu Yang, Zhanmei Zhou, Zhuoyu Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 341.0267 Law of nations
• Thông tin xuất bản: England : Journal of autoimmunity , 2025
• Bộ sưu tập: NCBI
• ID: 740376
• Chủ đề: 1. Glomerular; 2. Cd68; 3. Objective

Tóm tắt

OBJECTIVE: Predictive models of kidney response to standard immunosuppression are needed in proliferative lupus nephritis (LN). We tested the kidney macrophage infiltration at initial biopsy. METHODS: The prospective study was performed in 247 patients with newly diagnosed proliferative LN in 2 independent cohorts. Infiltrates of macrophages and lymphocytes in initial biopsies were identified using single-cell RNA sequencing and immunostaining analysis. The outcome was kidney response to standard immunosuppression at 1 year, defined clinically and histologically. Kidney infiltrates were investigated for association with kidney response. Models that combined kidney infiltrates and clinical parameters for predicting kidney response were developed and validated using machine learning algorithms. RESULTS: In Derivation cohort, glomerular infiltration of CD68 CONCLUSION: Intensity of glomerular CD68