Sudden cardiac arrest (SCA) represents a major cause of premature mortality globally, with an enormous effect on victims, families, and communities. Cardiac arrest prevention should be considered a health priority in Australia. A multi-faceted strategy will include community awareness, improved fundamental mechanistic understanding, preventive strategies, implementation of best-practice resuscitation strategies, secondary risk assessment of family members, and development of (near) real-time registries to inform areas of need and assess the effectiveness of interventions. Challenges of patient access to specialised care and equity within the Australian and New Zealand healthcare system should also be recognised.