Rapid shifts in evidence-based medicine challenge clinicians to adapt their practices based on new information. Synthesizing relevant evidence can drive clinical advancements. To enhance knowledge of practice-changing literature, a group of six internists reviewed titles and abstracts from seven internal medicine journals with the highest impact factors and relevance to outpatient general internal medicine. New England Journal of Medicine (NEJM), The Lancet, Annals of Internal Medicine, Journal of the American Medical Association (JAMA), JAMA Internal Medicine, British Medical Journal (BMJ), and Public Library of Science (PLoS) Medicine were reviewed. In addition, collections of article synopses and databases were also reviewed: American College of Physicians Journal Club, NEJM Journal Watch, BMJ Evidence-Based Medicine, McMaster ACCESSSS/DynaMed Evidence Alerts, and Cochrane Reviews. A modified Delphi method was used to reach consensus based on relevance to outpatient internal medicine, impact on practice, and strength of evidence. Articles pertaining to the same topic were considered together. In total,7 practice-changing articles were included.