riSCC: A personalized risk model for the development of poor outcomes in cutaneous squamous cell carcinoma.

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Tác giả: David G Brodland, Javier Cañueto, David R Carr, Joi B Carter, John A Carucci, Emily E Granger, Kelsey E Hirotsu, Anokhi Jambusaria-Pahlajani, Vincent Jeanselme, Emily E Karn, Shlomo A Koyfman, William Lotter, Aaron R Mangold, Fabio Muradás Girardi, Nina A Ran, Emily S Ruiz, Kathryn T Shahwan, Divya Srivastava, Allison T Vidimos, David M Wang, Tyler J Willenbrink, Ashley Wysong

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Journal of the American Academy of Dermatology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 740560

BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is a prevalent disease for which improved risk stratification strategies are needed. OBJECTIVE: To develop a novel prognostic model (herein "riSCC") for CSCC and compare riSCC performance to Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer Staging 8 METHODS: Retrospective 12-center, multinational cohort study of CSCCs from 1991 to 2023. Clinical and pathologic risk factors, treatments, and outcomes were collected. Fine-Gray model was employed for each outcome with inverse probability of treatment weighting. A final model was trained for prospective use and estimation of hazard ratios. RESULTS: 23,166 localized CSCC tumors were included. riSCC prognostic model performed superiorly to American Joint Committee on Cancer 8th edition and Brigham and Women's Hospital T staging for all outcomes. At five years, the C-index for riSCC ranged from 0.74 for LR to 0.87 for DSD. LIMITATIONS: Retrospective study design CONCLUSION: riSCC prognostic model offers fine-grained risk estimates and improved stratification for important CSCC outcomes compared to T staging systems.
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