ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling.

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Tác giả: Nai-Chuan Chang, Shih-Hsiang Chen, Tan-Chi Fan, Tsai-Hsien Hung, Yun-Hsin Tang, Hui Ling Yeo, Alice L Yu, John Yu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : The Journal of biological chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 740638

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Metastasis is a major cause of cancer-related morbidity and mortality. The overexpression of the sialyltransferase ST3GAL1 in breast cancer correlates with metastasis. However, the molecular mechanisms underlying the effect of ST3GAL1 on cell movement are poorly understood. We identified neuropilin-1/NRP1 as a substrate for ST3GAL1. Gene expression analysis revealed that recurrence-free survival (P = 0.0046) and distant metastasis-free survival (P = 0.0003) were significantly shorter in the ST3GAL1

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