Enhanced rivastigmine delivery through nanoemulsion and pyridoxine supplementation: An in-vivo study on Alzheimer's disease intervention.

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Tác giả: Tummala Lokeswari Naga Sai Anjana, Nirmala Jyothi Gade, Asha Gummadi, Shaik Haseena, Balaji Maddiboyina, Sisir Nandi, Bhabani Shankar Nayak, Harekrishna Roy, Swati Srungarapati, Kammula Mounika Vinayasri

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Nanomedicine : nanotechnology, biology, and medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 740649

Nanoemulsions are nanostructured material and stabilized colloidal in nature evolved as a highly desirable mechanism for the delivery of drugs. Our objective of the study deals with a successful Rivastigmine (RSG) loaded nanoemulsion which can effectively progress the treatment of AD patients. We developed nanoemulsion containing RSG by combining pyridoxine, an essential vitamin supplement for central nervous system development, with linseed oil, which functioned as the lipophilic phase in the nanoemulsion formulation. The optimal formulation having globular size of 202.3 nm was further evaluated by various analytical techniques, including zeta potential analysis, ATR, DSC, and XRD study. The study utilized the Morris Water Maze (MWM) model to assess the cognitive abilities of Long-Evans rats. The current investigation establishes that the utilization of RSG nanoemulsion incorporating blend of linseed oil and pyridoxine which reduced travel distance in animal mode and can be successfully contribute to therapeutic advancements in patients with AD.
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