Nutmeg (Myristica fragrans Houtt.) is widely cultivated in tropical regions and valued for its culinary and medicinal uses. However, its safety profile remains underexplored. This study aimed to evaluate the safety of nutmeg powder through in-silico toxicity predictions, acute oral toxicity, and a 13-week repeated-dose toxicity assessment. In the in-silico study, bioactive compounds identified via High-Performance Liquid Chromatography (HPLC) were analyzed for toxicity parameters using the ProTox II server. For acute toxicity, a single dose of nutmeg powder was administered to mice, with no mortality observed over 14 days, and an LD