The sensory system detects the internal and external environment of the body and the stimulus trigger feedback loops toward the set point to maintain homeostasis, but if taste sensitivity has changed, we may consume more nutrients or loss of appetite. These can lead metabolic syndrome or malnutrition, which can lead to frailty. In this review, we examined which of the five basic tastes (sweet, umami, bitter, sour, and salty) is affected by aging. Next, we summarize the effects of oral bacteria and tongue coating on taste, which can cause problems such as bad breath and aspiration pneumonia. Even healthy people can change their taste sensitivity and pose health risks if they continue to eat certain taste substances on a daily basis. Furthermore, we summarize research from the discovery of the taste of fatty acids to the present, and discuss how the involvement of taste in food intake regulation contributes to homeostasis through a literature survey. Recently, a gut-brain circuit for fat preference has been identified. In the intestine, fatty acids are sensed by the same receptors as those in the taste buds of the tongue, and nutritional information is sent to the brain via the vagus nerve. It is very interesting that nerves that convey fatty acid-specific information have been discovered. In this way, taste system of the tongue and nutrition-sensing in the digestive tract are very similar, so we think it will be very meaningful to progress research by referring to each other.