Preparation and characterization of immediate release 3D printed tablets using hot melt extruded amorphous cyclosporine a filament.

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Tác giả: Chang-Soo Han, Jin-Hyuk Jeong, Woong-Young Jung, Ji-Hyun Kang, Dong-Wook Kim, Chun-Woong Park, Yun-Sang Park, Kwang-Hwi Yoo

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Pharmaceutical development and technology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 741028

3D printing technology is gaining attention as a next-generation approach to drug formulation. Among 3D printing techniques, fused deposition modeling is cost-effective but depends heavily on suitable filaments. Hot melt extrusion enables filament production by incorporating poorly water-soluble drugs like cyclosporine A into polymers to form solid dispersions. However, achieving immediate release formulations with 3D printing remains challenging due to issues such as inadequate tablet disintegration or drug entrapment within the polymer matrix. This study aimed to develop and evaluate immediate release 3D-printed cyclosporine A tablets using HME filaments. Three parameters were modified in the 3D printing process: varying fill speeds, infill densities, and channel lengths. Filaments composed of Kollidon
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