Comparative dosimetric assessment of combined treatment modalities in cervical cancer radiotherapy for optimal organ protection.

• Tác giả: Iozsef Gazsi, Loredana G Marcu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 335.437 Comparative studies
• Thông tin xuất bản: Germany : Radiation and environmental biophysics , 2025
• Bộ sưu tập: NCBI
• ID: 741067
• Chủ đề: 1. Comparative; 2. Dosimetric; 3. Assessment

Tóm tắt

External radiotherapy combined with internal radiotherapy in cervical cancer can provide a boost to the target volume to increase tumour control. At the same time internal radiotherapy protects neighboring organs. The aim of the present study was to dosimetrically compare three external beam radiotherapy techniques each combined with internal radiotherapy to evaluate the combination that offers the best organ protection. Treatment plans of 20 cervical cancer patients were created for external (including three-dimensional conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT)) as well as brachytherapy. The prescribed dose was 50 Gy in 25 fractions for external and 21 Gy in three fractions for internal radiotherapy. The following organs at risk (OARs) were evaluated: bladder, rectum, sigmoid and bowel bag. The study analyzed the results of different treatment combinations in terms of dosimetric values for various parameters. The D