HCN4 channels sense temperature and determine heart rate responses to heat.

• Tác giả: Eric Nunez Aguilar, Mark E Anderson, Mario A Bianchet, Jonathan Granger, Gabriel Lopez-Cecetaite, Andreas Ludwig, Anna Moroni, Oscar Reyes Gaido, Qinchuan Wang, Yuejin Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.11215 Engineering mechanics and materials
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 741185
• Chủ đề: 1. Hcn4; 2. Channels; 3. Sense

Tóm tắt

The hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (HCN4) current increases due to cAMP binding and is well-recognized to contribute to adrenergically driven heart rate acceleration. HCN4 current also increases with heat by an unknown mechanism(s). We use thermodynamical and homology computational modeling, site-directed mutagenesis, and mouse models to identify a concise motif on the S4-S5 linker of HCN4 channels (M407/Y409) that determines HCN4 current (I