Patients are central to healthcare services, and comprehending their perceptions is crucial for fostering effective value co-creation. This study aimed to investigate the user characteristics and perceptions of value co-creation within the context of Mobile Electronic Health Records (EHR). Using a questionnaire collected from 422 patients, the study employed the K-modes clustering algorithm in R-Studio to group users based on shared characteristics and perceptions of value co-creation. The analysis revealed three distinct user clusters, which are high familiarity-positive perception, low familiarity-positive perception and high familiarity-neutral to negative perception. These clusters characterized by unique attributes such as socio-economic, history of medical visit, intention to use, technological familiarity, and different perception of value co-creation in Mobile EHR systems. Descriptive statistics were used to further interpret the clusters, revealing differences in user characteristics and perception across cluster. The findings emphasize the importance of alignment between user expectations and system interactions. Effective alignment fosters value co-creation through resource access, sharing, integration, and recombination, while misalignment may result in value destruction. This study highlights the need to design and implement Mobile EHR systems that align with the diverse characteristics and of their users to enhance engagement and promote value co-creation.