Validation of a whole blood coagulometer sensitive to the direct oral anticoagulants.

• Tác giả: Jack Ansell, Sasha H Bakhru, Lirong Chen, Xuan Jiang, Kelly Kronen, Daryl Mootoo, Dardan Osmani, Stefan Zappe
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.338 Systems analysis and design, computer architecture, performance evaluation of real-time computers
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 741220

Tóm tắt

 Readily available and rapid turn-around, bedside assays to measure the effect of the direct oral anticoagulants (DOACs) are not available. This study evaluates a point-of-care (PoC) coagulometer to assess the anticoagulant effects of the DOACs and low molecular weight heparin. Studies were done in fresh spiked blood from healthy volunteers. PoC coagulometer baseline clotting times were half that of the manual whole blood clotting time (WBCT, legacy method) and exhibited a sensitivity to DOAC anticoagulation approximately twice that of WBCT. All %CV values for both methods were <
  10% with most being <
  5% indicating acceptable precision of both methods. R