A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models.

• Tác giả: Abdulrahman Al-Ammari, Chuntao Chen, Weixiao Ding, Yuwen Gai, Xinmeng Li, Xiaoling Ma, Dongping Sun, Qingqing Yu, Hongsong Zhang, Jiaan Zhang, Lei Zhang, Xu Zhi, Peng Zhou, Danxuan Zhu, Wanying Zhu, Chao Zuo
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 741226

Tóm tắt

Vaccines offer prophylactic treatments against atherosclerosis by eliciting effector T cell and antibody responses, which require effective delivery of antigen and adjuvant to activate dendritic cells (DC). Here we show that individual conjugation of antigen p210 and adjuvant CpG oligodeoxynucleotides onto superparamagnetic iron oxide nanoparticles formulates a nanovaccine cocktail that activates DCs for antigen cross-presentation and induction of co-stimulatory signals, cytokines and CD8