In this paper, a novel aluminum foam structure with wave attenuation and ventilation performance suitable for underground space is designed and prepared. It focuses on dynamic response of aluminum foam structure under explosion impact load and ventilation resistance at different wind speeds. Failure modes of each component are analyzed and attenuation mechanism of explosive shock wave are revealed. The results indicate that: under the synergistic action of the crushing behavior of the aluminum foam cells, the rough wall structure of the ventilation holes and the special diagonal square honeycomb-shaped structure, the wave attenuation effect of the aluminum foam structure is significantly improved. The max wave attenuation rate can reach to 99.1%. For this aluminum foam structure, the wind speeds are 4.32 m/s and 9.31 m/s while the ventilation resistances are 119.46 Pa and 641.44 Pa. It indicates its excellent ventilation performance. Therefore, the novel aluminum foam structure has a good application prospect in underground space construction.